MiNa Faculty Member

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Carl Hansen

University of British Columbia Physics and Astronomy 6224 Agricultural Rd Vancouver, British Columbia V6T-1Z1, Canada chansen@physics.ubc.ca http://www.physics.ubc.ca/~chansen Email: Education Bachelors Degree: UBC (2000) Engineering Physics / Electrical Engineering / Honors Math Masters Degree: Caltech (2004) Applied Physics Doctoral Degree: Caltech (2004) Applied Physics Research Interests Our research is focused on the development of new microsystems tools for biology and on the validation of these tools in the context of outstanding problems in biology and medicine. Biophysics and Biotechnology, Microsystems Technology for Biological Applications, Structural Biology, Single-Cell Analysis, Molecular Diagnostics Courses

Group Members: Kaston Leung, Ph.D. student Anupam Singhal, Ph.D. student Adam White, M.A.Sc. student Alumni:

Research Projects

Journal Publications

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2009

Diercks A.H., Ozinsky A., Hansen C.L., Spotts J.M., Rodriguez D.J., Aderem A., "A microfluidic device for multiplexed protein detection in nano-liter volumes", Anal Biochem, 2009. Tagged XML BibTex

R. J. Taylor, D. Falconnet, A. Niemisto, S. A. Ramsey, S. Prinz, I. Shmulevich, T. Galitski,1, and C. L. Hansen, "Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform", Proc Natl Acad Sci USA, 2009. Tagged XML BibTex

2008

F. Kuchenbauer, R. D. Morin, B. Argiropoulos, O. I. Petriv, M. Griffith, M. Heuser, E. Yung, J. Piper, A. Delaney, A. Prabhu, Y. Zhao, H. McDonald, T. Zeng, M. Hirst, C. L. Hansen, M. A. Marra, and R. K. Humphries, "In-depth characterization of the microRNA transcriptome in a leukemia progression model", Genome Research, 2008. Tagged XML BibTex

2007

Lau, B. T. C., Baitz, C. A., Dong, X. P., Hansen, C. L., "A complete microfluidic screening platform for rational protein crystallization", Journal of the American Chemical Society, vol. 129, no. 3, pp. 454-455, 2007  . Tagged XML BibTex

2006

Hansen, C. L., Classen, S., Berger, J. M., Quake, S. R., "A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination", Journal of the American Chemical Society, vol. 128, no. 10, pp. 3142-3143, 2006  . Tagged XML BibTex

Anderson, M. J., Hansen, C. L., Quake, S. R., "Phase knowledge enables rational screens for protein crystallization", Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 45, pp. 16746-16751, 2006  . Tagged XML BibTex

2005

Balagadde, F. K., You, L. C., Hansen, C. L., Arnold, F. H., Quake, S. R., "Long-term monitoring of bacteria undergoing programmed population control in a microchemostat", Science, vol. 309, no. 5731, pp. 137-140, 2005  . Tagged XML BibTex

Anderson, M. J., Hansen, C. L., Quake, S. R., "The use of microfluidic devices towards protein crystallography", Biophysical Journal, vol. 88, no. 1, pp. 55A-55A, 2005  . Tagged XML BibTex

2004

Hansen, C. L., Sommer, M. O. A., Quake, S. R., "Systematic investigation of protein phase behavior with a microfluidic formulator", Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 40, pp. 14431-14436, 2004  . Abstract Tagged XML BibTex

2003

Hansen, C.L., Sommer, M., Self, K., Berger, J.M., Quake, S. R., "Micro-crystallization", Protein Crystallography in Drug Discovery, Weinheim, Wiley-VCH, 2003  . Tagged XML BibTex

Hansen, C., Quake, S. R., "Microfluidics in structural biology: smaller, faster... better", Current Opinion in Structural Biology, vol. 13, no. 5, pp. 538-544, 2003  . Tagged XML BibTex

Liu, J., Hansen, C., Quake, S. R., "Solving the "world-to-chip" interface problem with a microfluidic matrix", Analytical Chemistry, vol. 75, no. 18, pp. 4718-4723, 2003  . Abstract Tagged XML BibTex

2002

Hansen, C.L., Skordalakes, E., Berger, J.M., Quake, S.R., "A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion", Proceedings of the National Academy of Sciences of the United States of America, vol. 99, pp. 16531-16536, 2002  . Tagged XML BibTex

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5 years 40 weeks