MiNa Faculty Member
Dr. Eric Lagally
Michael Smith Laboratories &
Department of Chemical and Biological Engineering
#301 - 2185 East Mall
The University of British Columbia
Vancouver, BC V6T 1Z4
Phone: (604) 827-4274
Licensed Professional Engineer in British Columbia
PhD in Bioengineering, University of California, Berkeley and -San Francisco, 2003
B.S. Physics, Washington University in St. Louis, 1998
Our group uses integrated microsystems to probe the biology of cells and molecules. Our current research focuses in two areas, affinity reagent selection and detection of bacterial pathogens. Integrated microfluidics consisting of etched glass channels and microchambers with PDMS microvalve technologies allow for adaptable systems capable of performing complicated assays in a fraction of the time of conventional systems. Our eventual goal is to use such microsystems to define, probe, and predict biological networks of complex diseases by simultaneous detection of many facets of cell biology in parallel.
CHBE 559M - Microfluidic Reactors
CHBE 357 - Interfacial Phenomena
Microfluidic electrochemical sensors for early detection of prostate cancer By integrating multiple molecular biology assay steps on a single microfluidic platform, we aim to detect the activity of telomerase, an enzyme upregulated in prostate cancer cells. This will hopefully provide detection of prostate cancer than currently possible, and demonstrate better specificity for cancer than prostate-specific antigen (PSA) tests. Detection and characterization of pathogenic bacteria Electrokinetic methods for isolation, concentration, and purification of pathogenic bacteria from complex media. Fabrication of integrated microfluidics for front-end purification followed by genetic and immunological characterization. Microfluidic aptamer selection We are developing integrated microfluidic systems for the rapid and high-efficiency selection of nucleic acid aptamers.
Journal Publications(Table View)In Press"Multiplexed surface plasmon resonance imaging for protein biomarker analysis", Methods in Molecular Biology: Microfluidic Diagnostics: Humana Press, In Press .2011"Photocurrent generation by direct electron transfer using photosynthetic reaction centres", SMART MATERIALS \& STRUCTURES, vol. 20, no. 9, SI, SEP.2010"Detection of telomerase activity in highly concentrated cell lysates using primer-modified gold nanoparticles", Journal of the American Chemical Society, vol. 132, issue 43, pp. 15299-15307, 12/2010."Jell-O microfluidics and synthetic biology: combining science outreach with basic research", Bioanalysis, vol. 2, pp. 1671-1672, 09/2010."Novel Carboxyl-Amine Bonding Methods for Poly(dimethylsiloxane)-Based Devices", Langmuir, vol. 26, issue 14, pp. 11609-11614, 08/2010."Parallel microfluidic arrays for SPRi detection", Proceedings of SPIE, vol. 7759, San Deigo, CA, 08/2010."Using Inexpensive Jell-O Chips for Hands-On Microfluidics Education", Analytical Chemistry, vol. 82, issue 13, pp. 5408-5414, 07/2010."Parallel integrated microfluidic surface plasmon resonance imaging arrays", Lab on a Chip, vol. 10, issue 5, pp. 581-588, 05/2010."Parallel microfluidic arrays for SPRi detection", Proceedings of SPIE, vol. 7682, 03/2010.2009"Micromagnetic Selection of Aptamers in Microfluidic Channels", Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 2989-2994, 01/2009.2008"Parallel microfluidic arrays for SPRi detection", Proceedings of SPIE, vol. 7035, San Diego, CA, USA, pp. 703505-1, 12/08/2008."Fluid control structures in microfluidic devices", US Patent 7,445,926, 2008 .2007"Microfluidic Screening of Aptamer Libraries", Proceedings of Micro-Total Analysis Systems 2007, Paris, France, CMBS, 07/10/2007.2006"Rapid, sequence-specific detection of unpurified PCR amplicons via a reusable, electrochemical sensor", Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 11, pp. 4017-4021, 2006 .2005"Integrated Microsystem for Dielectrophoretic Cell Concentration and Genetic Detection", Lab on a Chip, vol. 5, pp. 1053-1058, 2005 ."Integrated Genetic Analysis Microsystems", Critical Reviews in Solid State and Materials Sciences, vol. 30, pp. 207-233, 2005 ."Microfluidic Genetic Analysis with an Integrated a-Si:H Detector", Biomedical Microdevices, vol. 7, no. 2, pp. 147-152, 2005 .2004"Integrated Genetic Analysis Microsystems", Journal of Physics D: Applied Physics, vol. 37, no. 23, pp. R245-R261, 2004 ."Integrated Portable Genetic Analysis Microsystem for Pathogen/Infectious Disease Detection", Analytical Chemistry, vol. 76, no. 11, pp. 3162-3170, 2004 .2003"Monolithic Membrane Valves and Diaphragm Pumps for Practical Large-Scale Integration into Microfluidic Devices", Sensors and Actuators B-Chemical, vol. 89, pp. 315-323, 2003 .2001"Fully Integrated PCR-capillary electrophoresis microsystem for DNA analysis", Lab on a Chip, vol. 1, no. 2, pp. 102-107, 2001 ."Single-molecule DNA amplification and analysis in an integrated microfluidic device", Analytical Chemistry, vol. 73, no. 3, pp. 565-570, 2001 .2000"Monolithic integrated microfluidic DNA amplification and capillary electrophoresis analysis system", Sensors and Actuators B-Chemical, vol. 63, no. 3, pp. 138-146, 2000 .
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