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Eric.Lagally

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MiNa Faculty Member

Dr. Eric Lagally

Michael Smith Laboratories &
Department of Chemical and Biological Engineering
#301 - 2185 East Mall
The University of British Columbia
Vancouver, BC V6T 1Z4

Phone: (604) 827-4274

Email:

Education

Licensed Professional Engineer in British Columbia
PhD in Bioengineering, University of California, Berkeley and -San Francisco, 2003
B.S. Physics, Washington University in St. Louis, 1998

Research Interests

Our group uses integrated microsystems to probe the biology of cells and molecules. Our current research focuses in two areas, affinity reagent selection and detection of bacterial pathogens. Integrated microfluidics consisting of etched glass channels and microchambers with PDMS microvalve technologies allow for adaptable systems capable of performing complicated assays in a fraction of the time of conventional systems. Our eventual goal is to use such microsystems to define, probe, and predict biological networks of complex diseases by simultaneous detection of many facets of cell biology in parallel.

Courses

CHBE 559M - Microfluidic Reactors
CHBE 357 - Interfacial Phenomena

 Dr. Eric Lagally

Group Members:

Alumni:

    Research Projects
    Microfluidic electrochemical sensors for early detection of prostate cancerBy integrating multiple molecular biology assay steps on a single microfluidic platform, we aim to detect the activity of telomerase, an enzyme upregulated in prostate cancer cells. This will hopefully provide detection of prostate cancer than currently possible, and demonstrate better specificity for cancer than prostate-specific antigen (PSA) tests.
    Detection and characterization of pathogenic bacteriaElectrokinetic methods for isolation, concentration, and purification of pathogenic bacteria from complex media. Fabrication of integrated microfluidics for front-end purification followed by genetic and immunological characterization. DEP setup
    Microfluidic aptamer selectionWe are developing integrated microfluidic systems for the rapid and high-efficiency selection of nucleic acid aptamers.

    Journal Publications

    (Table View)
    In Press
    Eric Ouellet, Louise Lund, Eric T. Lagally, "Multiplexed surface plasmon resonance imaging for protein biomarker analysis", Methods in Molecular Biology: Microfluidic Diagnostics: Humana Press, In Press  . Tagged XML BibTex
    2011
    Mahmoudzadeh, A., Saer, R., Jun, D., Mirvakili, S. M., Takshi, A., Iranpour, B., Ouellet, E., Lagally, E. T., Madden, J. D. W., Beatty, J. T., "Photocurrent generation by direct electron transfer using photosynthetic reaction centres", SMART MATERIALS \& STRUCTURES, vol. 20, no. 9, SI, SEP. Abstract Tagged XML BibTex
    2010
    Y. Xiao, K. Dane, T. Uzawa, A. Csordas, J. Qian, H.T. Soh, P. Daugherty, E.T. Lagally, A. Heeger, K.W. Plaxco, "Detection of telomerase activity in highly concentrated cell lysates using primer-modified gold nanoparticles", Journal of the American Chemical Society, vol. 132, issue 43, pp. 15299-15307, 12/2010. Tagged XML BibTex
    Eric T. Lagally, Joanne A. Fox, "Jell-O microfluidics and synthetic biology: combining science outreach with basic research", Bioanalysis, vol. 2, pp. 1671-1672, 09/2010. Tagged XML BibTex
    Eric Ouellet, Cheng Wei T. Yang, Tao Lin, Lee Ling Yang, Eric T. Lagally, "Novel Carboxyl-Amine Bonding Methods for Poly(dimethylsiloxane)-Based Devices", Langmuir, vol. 26, issue 14, pp. 11609-11614, 08/2010. Tagged XML BibTex
    Eric T. Lagally, Eric Ouellet, Christopher Lausted, Cheng Wei T. Yang, Tao Lin, Helen L. Lund, Leroy Hood, "Parallel microfluidic arrays for SPRi detection", Proceedings of SPIE, vol. 7759, San Deigo, CA, 08/2010. Tagged XML BibTex
    Cheng Wei T. Yang, Eric Ouellet, Eric T. Lagally, "Using Inexpensive Jell-O Chips for Hands-On Microfluidics Education", Analytical Chemistry, vol. 82, issue 13, pp. 5408-5414, 07/2010. Tagged XML BibTex
    Eric Ouellet, Christopher Lausted, Tao Lin, Cheng Wei Tony Yang, Leroy Hood, Eric T. Lagally, "Parallel integrated microfluidic surface plasmon resonance imaging arrays", Lab on a Chip, vol. 10, issue 5, pp. 581-588, 05/2010. Tagged XML BibTex
    Eric Ouellet, Christopher Lausted, Leroy Hood, Eric T. Lagally, "Parallel microfluidic arrays for SPRi detection", Proceedings of SPIE, vol. 7682, 03/2010. Tagged XML BibTex
    2009
    Lou, X, Viel, Lisan, Qian, Jiangrong, Gerdon, Aren, Lagally, Eric T., Tok, J.B.-H., Tarasow, T., Heeger, A.J., Soh, H.T., "Micromagnetic Selection of Aptamers in Microfluidic Channels", Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 2989-2994, 01/2009. Tagged XML BibTex
    2008
    Ouellet, E., Lausted, C., Hood, L., Lagally, E.T., "Parallel microfluidic arrays for SPRi detection", Proceedings of SPIE, vol. 7035, San Diego, CA, USA, pp. 703505-1, 12/08/2008. Tagged XML BibTex
    Richard A. Mathies, William H. Grover, Brian Paegel, Alison Skelley, Eric T. Lagally, Chung N. Liu, Robert Blazej, "Fluid control structures in microfluidic devices", US Patent 7,445,926, 2008  . Tagged XML BibTex
    2007
    Lou, X., Viel, L., Qian, J., Lagally, E.T., H-Tok, J.B., Tarasow, T.M., Heeger, A.J., Soh, H.T., "Microfluidic Screening of Aptamer Libraries", Proceedings of Micro-Total Analysis Systems 2007, Paris, France, CMBS, 07/10/2007. Tagged XML BibTex
    2006
    Lai, R. Y., Lagally, E. T., Lee, S. H., Soh, H. T., Plaxco, K. W., Heeger, A. J., "Rapid, sequence-specific detection of unpurified PCR amplicons via a reusable, electrochemical sensor", Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 11, pp. 4017-4021, 2006  . Abstract Tagged XML BibTex
    2005
    Lagally, E. T., Lee, S. H., Soh, H. T., "Integrated Microsystem for Dielectrophoretic Cell Concentration and Genetic Detection", Lab on a Chip, vol. 5, pp. 1053-1058, 2005  . Tagged XML BibTex
    Lagally, E. T., Soh, H. T., "Integrated Genetic Analysis Microsystems", Critical Reviews in Solid State and Materials Sciences, vol. 30, pp. 207-233, 2005  . Tagged XML BibTex
    Kamei, T., Toriello, N.M., Lagally, E. T., Blazej, R. G., Scherer, J.R., Street, R. A., Mathies, R. A., "Microfluidic Genetic Analysis with an Integrated a-Si:H Detector", Biomedical Microdevices, vol. 7, no. 2, pp. 147-152, 2005  . Tagged XML BibTex
    2004
    Lagally, E. T., Mathies, R. A., "Integrated Genetic Analysis Microsystems", Journal of Physics D: Applied Physics, vol. 37, no. 23, pp. R245-R261, 2004  . Tagged XML BibTex
    Lagally, E.T., Scherer, J. R., Blazej, R.G., Toriello, N.M., Diep, B.A., Ramchandani, M., Sensabaugh, G.F., Riley, L.W., Mathies, R. A., "Integrated Portable Genetic Analysis Microsystem for Pathogen/Infectious Disease Detection", Analytical Chemistry, vol. 76, no. 11, pp. 3162-3170, 2004  . Tagged XML BibTex
    2003
    Grover, W. H., Skelley, A. M., Liu, C. N., Lagally, E.T., Mathies, R. A., "Monolithic Membrane Valves and Diaphragm Pumps for Practical Large-Scale Integration into Microfluidic Devices", Sensors and Actuators B-Chemical, vol. 89, pp. 315-323, 2003  . Tagged XML BibTex
    2001
    Lagally, E.T., Emrich, C.A., Mathies, R.A., "Fully Integrated PCR-capillary electrophoresis microsystem for DNA analysis", Lab on a Chip, vol. 1, no. 2, pp. 102-107, 2001  . Tagged XML BibTex
    Lagally, E. T., Medintz, I., Mathies, R. A., "Single-molecule DNA amplification and analysis in an integrated microfluidic device", Analytical Chemistry, vol. 73, no. 3, pp. 565-570, 2001  . Abstract Tagged XML BibTex
    2000
    Lagally, E. T., Simpson, P. C., Mathies, R. A., "Monolithic integrated microfluidic DNA amplification and capillary electrophoresis analysis system", Sensors and Actuators B-Chemical, vol. 63, no. 3, pp. 138-146, 2000  . Abstract Tagged XML BibTex

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